PROBIOTICS in antibiotics associated diarrhea

Diarrhoea is a common occurrence in association with antibiotic administration. Earlier studies and meta-analyses have suggested that probiotic administration reduces the incidence of antibiotic-associated diarrhoea (AAD).

Antibiotic-associated diarrhoea (AAD) remains a prevalent condition in both in-patient and out-patient settings. The prevalence of AAD is estimated at 5–39% and is associated with increased costs and hospital length of stay. AAD is a separate clinical entity from Clostridium difficile (C. difficile)-induced diarrhoea and from C. difficile-associated pseudomembranous colitis. The occurrence of AAD can be a limiting factor to adherence to antibiotic regimens and to successful completion of treatment.

Probiotics are 'live microorganisms, which, when consumed in adequate amounts, confer a health benefit on the host'. Probiotic administration has been linked to modulation of gut mucosal immunity, barrier function, metabolism and direct interaction with pathogenic bacteria. These effects have been the rationale for the use of probiotics in a variety of conditions affecting the gastrointestinal tract, including travellers' diarrhoea, inflammatory bowel disease, irritable bowel syndrome, bacterial overgrowth and C. difficile infection.

Probiotics have been used empirically for the treatment and prevention of AAD. 

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Intramuscular Midazolam in Status epilepticus: as effective as intravenous lorazepam for the initial treatment of status epilepticus.
Status epilepticus is a medical emergency associated with significant morbidity and mortality. It is defined as "a single epileptic seizure of >30-min duration or a series of epileptic seizures during which function is not regained between ictal events in a >30-min period." Currently, epileptologists advise that seizures lasting longer than 5 minutes may not be self-limited and should be treated as status epilepticus.

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A very common problem faced by post menopausal women is recurrent UTIs. Low-dose antibiotics (nitrofurantoin or trimethoprim/sulfamethoxazole) remain the gold standard in prevention. Topical estrogens have been proven in at least 2 small randomized controlled trials to reduce urinary tract infections by one third to three quarters. Probiotics are also being used for the same. To know more, mail to meditextchd@gmail.com. We will provide you with the latest medical matter with complete references.

Artemether + Lumefantrine available in the following compositions:

Artemether 40mg/80mg + Lumefantrine 240mg/480mg available as film coated tablets as well as dispersible tablets. It is the most potential seasonal medicine for malaria available these days. For complete medical aid on the same, kindly mail to meditext@gmail.com. We offer to provide the latest research medical matter on the same with complete references.

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